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Related post: have two loci determining the expression of infectious X-MuLV. In crosses
with other inbred X-MuLV strains, NZB high expression of these two loci
segregates as Mendel in dominants. By comparison, crosses of additional
strains (F/St, BXD-14, NZW or M.M. molossinus) expressing moderate to high
levels of infectious X-MuLV show that high expression is markedly suppressed
in young F, mice and mice in the backcross to the low X-MuLV present. The
possibility that the product of a single locus may suppress the high X-MuLV
phenotype of non-NZB strains is under investigation.
Studies of expression of gp70 antigens coded for by X-MuLV . XenCSA and G.^
are two determinants of gp70 molecules coded for by endogenous X-MuLV.
Studies of mice from crosses segregating for quantitative expression of
XenCSA and G.^ confirmed previous work demonstrating that XenCSA levels are
controlled by a gene linked to Gpd-1 on chromosome k. For G.^, a similar
effect was observed for mice from one cross (B6 X DBA/2) but not another
(B6 X C3H) . These results indicate independent genetic control of two
cell-surface markers for X-MuLV.
Other studies of spleen cells stimulated with PHA, Con A, or LPS showed that
XenCSA expression is markedly increased by Con A and PHA but Thorazine Cost only sightly
increased by LPS stimulation. Cell surface antigens coded for by X-MuLV
may thus serve as markers for activation of T lymphocytes independent of
increased production of infectious or X-MuLV.
Studies of neurotropic wild mouse ecotropic MuLV . NFS mice injected as
newborns with CAS-BR-M, a wild mouse ecotropic MuLV, develop hind limb
paralysis and lymphomas after 2-3 months. During this latent period, the
level of XenCSA on spleen cells, but Thorazine Mg not thymocytes, increases markedly.
This increase is associated with the appearance in spleen extracts, of
antigens related to the gp70's of recombinant, mink cell focus-inducing
(MCF) MuLV. MCF antigens were also detected in brains of older mice with
paralysis. The possible role of recombinant MuLV in the development of
paralysis is under investigation.
Resistance to MCF MuLV . Cells of DBA/2 and DBA/1 mice, as compared to those
of NFS, AKR or some other inbred strains, are highly resistant to infection
with MCF MuLV. Resistance is controlled by a single dominant gene.
Studies are in progress to map this gene and determine its effect on
spontaneous development of lymphomas.
Project No. ZOl Al OOI38-O6 LMI
Publ ications :
Elder, J. H., Gautsch, J. W., Jensen, F. C, Lerner, R. A., Chused, T. M,
Morse, H. C, Hartley, J. W., and Rowe, W, P.: Differential expression
of two distinct xenotorpic viruses in NZB mice. Clin. Immunol, and
Immunopath. 15: ^93-501, I98O.
Longstreth, J. D., and Morse, H.C. ill.: Murine leukemia viruses of
inbred mice, in press I98O.
SMITHSONIAN SCItNCE IMFOffMATION EXCHANGE
PROJECT NUNiBER (Oo NOT use this space)
U.S. DEPARTMENT OF
HEALTH, EDUCATION, AND WELFARE
PUBLIC IICALTfl SERVICE
INTRAMURAL RESEARCH PfiOJECT
PROJE' T NUMBER
ZOl Al 00139-15 LMI
October 1, 1979 to September 30, I98O
TITLE OF PROJECT (80 characters or less)
The Immunologic Response of Animals to Trypanosomal Antigens
NAMES, LABORATORY AND INSTITUTE AFFILIATIONS, AND TITLES OF PRINCIPAL INVESTIGATORS AND ALL OTHER
PROFESSIONAL PERSONNEL ENGAGED ON THE PROJECT
Research Microbiologist LMI/NIAID
Research Microbiologist LPD/NIAID
Visiting Associate LMI/NIAID
Visiting Fellow LPD/NIAID
Visiting Scientist IB/NCI
P. Thorazine Tablets Gasbarre*
Me 1 V i n''"''*
COOPERATING UNITS (if any)
* WHO Immunology Research & Training Center, Lausanne, Switzerland
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